```html PrecisionGEN Solutions | Genomic Interpretation for Biopharma & Cell Therapy PrecisionGEN Solutions | Genomic Interpretation for Biopharma & Cell Therapy

AI runs the pipeline. We interpret the biology.

Physician-scientist–led genomic oversight for cell therapies, oncology programs, and high-stakes therapeutics. We combine long-read WGS, short-read WGS, and RNA-seq as a single integrated lens — finding what automated pipelines and single-platform approaches routinely miss.

Explore ServicesBook a 20-Min Consult
0
Years in clinical genomics
0
Exomes & genomes analyzed
11+
Novel disease genes discovered
Global
US • Europe • MENA

 

Our Philosophy: Beyond the Button-Click

We are entering an era where AI can run workflows, annotate genomes, and call variants with a single click. And that is great — because button-click bioinformatics was never the real job.

At PrecisionGEN, bioinformatics is not just computation — it is biological reasoning powered by computation. What AI cannot replace is what happens after the pipeline runs. We combine long-read sequencing, RNA-seq, and short-read data not as separate analyses but as a single integrated lens. Structural variants, deep intronic mutations, and low-frequency mosaicism only become visible when you look across all layers simultaneously. AI automates the steps. We design the biological story.

Specialized Capabilities

Standard pipelines are built for inherited genetics and single-platform data. We bring long-read sequencing, RNA-seq, and clinical-grade reasoning to the problems that matter most.

🧬

Cell Line & iPSC Genomic Stability

During reprogramming, expansion, and differentiation, engineered cell lines silently accumulate somatic mutations. Standard short-read pipelines routinely miss the low-frequency mosaicism and structural rearrangements that trigger tumorigenicity and derail FDA IND applications. We apply long-read WGS and custom somatic variant calling to find what black-box software ignores.

Benefit: De-risk your cell banks and IND submission before the FDA asks the question.

🔬

Advanced Cancer Genome Profiling

We deliver end-to-end expert analysis of tumor genomes — from raw data to a biologically coherent model of clonal evolution and drivers. Long-read WGS combined with RNA-seq uncovers cryptic structural variants, deep intronic mutations, and complex fusions that short-read pipelines miss entirely.

Benefit: Turn sequencing data into a biological decision, not just a variant list.

🎯

Complex Variant Characterization & VUS Resolution

Variants of unknown significance stall decisions in rare disease and oncology. We integrate DNA, RNA-seq, long-read cDNA sequencing, phenotype, and literature to turn ambiguous variants into defensible conclusions — including deep intronic splice-altering mutations invisible to DNA alone. Ideal for stalled rare disease cases, hereditary cancer panels, and ambiguous findings in clinical trial genomics.

Benefit: Convert ambiguity into a defensible, clinically actionable conclusion.

📈

Strategic R&D Genomics Consulting

Target validation, biomarker discovery, pipeline audits, and integrative multi-omics analysis for publications, grants, and regulatory packages. We plug into your R&D process and provide the expert biological interpretation layer that automated tools cannot supply.

Benefit: Increase discovery yield, de‑risk programs, and move from data to decision faster.

How We Work

1

Confidential Scoping

A 20-minute call to understand your challenge, data type, and timeline — no obligation, and under NDA as needed. You receive a fixed-fee proposal and Statement of Work within 48 hours.

2

Integrated Analysis

Our physician-scientist manages the full analytical journey — QC, multi-platform integration (long-read WGS, RNA-seq, short-read), variant calling, and biological reasoning. Regular updates keep you aligned throughout.

3

Biological Narrative & Debrief

A clear, actionable report plus a live debrief call to discuss findings, implications, and recommended next steps. Science and conclusions — not just data dumps.

Who We Serve

🏢

Cell Therapy & Regenerative Medicine Startups

Your dedicated genomic QC partner — helping de-risk therapeutic pipelines before millions are spent on clinical trials. We know what the FDA will ask about cell line stability. We find the issues before they do.

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Biopharma & CROs

Strategic genomics interpretation for complex oncology and rare disease drug targets. We provide the deep biological reasoning layer that automated tools cannot supply, freeing internal teams from expert-level interpretation.

🎓

Precision Oncology Programs & Academic Labs

Expert somatic interpretation and multi-omics integration for translational research, academic-industry collaborations, and grant-funded programs. Turn complex datasets — including long-read data — into publications and funded proposals without hiring permanent staff.

Founder

Suleyman Gulsuner, MD, PhD

Physician-scientist · Clinical genomics & computational biology · Academic medical center faculty

About the Founder

  • ✓Interpreted over 15,000 exomes and genomes — providing diagnoses and informing treatment strategies across rare disease and oncology.
  • ✓Lead analytical role in the discovery of 11+ novel disease genes, published in Science, Cell, PNAS, Genome Research, and Nature Genetics.
  • ✓Pioneered clinical application of long-read sequencing combined with RNA-seq to resolve structural variants and deep intronic mutations that standard pipelines cannot detect — giving you access to methods already validated in peer-reviewed clinical genomics.
  • ✓Architect of bioinformatics workflows for targeted RNA-seq panels including cBROCA, enabling systematic discovery of splice-altering mutations in cancer predisposition genes.
  • ✓Based at a leading academic medical center, with independent consulting conducted through PrecisionGEN Solutions, LLC.
  • ✓NIH & DoD-funded work across diverse global populations — US, Europe, MENA, and South Asia.

Start with a 20-minute conversation

Every engagement begins with a confidential scoping call. No obligations. No jargon.

Get in touch

  • ✉️contact@precisiongensolutions.com
  • 🌍US • Europe • MENA

What to expect

A confidential Zoom call to understand your challenge and data. Scoping proposal returned within 48 hours. All engagements are project-scoped and priced per engagement — contact us for a proposal.

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